2024
Zhen Xia*, Qihan Jin*, Zhilin Long, Yexuan He, Fuyi Liu, Chengfang Sun, Jinyang Liao, Chun Wang, Chentong Wang, Jian Zheng, Weixi Zhao, Tianxin Zhang, Jeremy N. Rich, Yongdeng Zhang, Longxing Cao#, Qi Xie# . Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders. Nature Biomedical Engineering, 17 October (2024), https://www.nature.com/articles/s41551-024-01258-8 (#Corresponding author)
Peng Lin*, Wenyan Chen*, Zhilin Long, Jichuan Yu, Jiayao Yang, Zhen Xia, Qiulian Wu, Xinyu Min, Jing Tang, Ya Cui, Fuyi Liu, Chun Wang, Jian Zheng, Wei Li, Jeremy N. Rich#, Lei Li#, Qi Xie# . RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation. Cell Discovery, 19 March (2024), https://www.nature.com/articles/s41421-024-00654-3 (#Corresponding author)
2023
Xiaojuan Ran*, Jian Zheng*, Lingchao Chen*, Zhen Xia*, Yin Wang, Chengfang Sun, Chen Guo, Peng Lin ... Qi Xie# . Single-cell transcriptomics reveals the heterogeneity of the immune landscape of IDH-wildtype high-grade gliomas. Cancer Immunol Res, 13 December (2023), https://doi.org/10.1158/2326-6066.CIR-23-0211. (#Corresponding author)
Lihui Liu*, Ziyang Liu*, Qinghua Liu*, Wei Wu*, Peng Lin* ... Qi Xie# Tao Jiang#, Runsheng Chen#. LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2’-O-methylation. Nat Commun, 18 November (2023), https://doi.org/10.1038/s41467-023-43113-5. (#Co-corresponding author)
2022
Zhilin Long*, Chengfang Sun, Min Tang, Yin Wang, Jiayan Ma, Jichuan Yu, Jingchao Wei, Jianzhu Ma, Bohan Wang#, Qi Xie#, Jiaming Wen#. Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma, Cell Discovery, 19 July 2022, https://doi.org/10.1038/s41421-022-00415-0. (#Co-corresponding author)
Bernareggi, D.*, Xie, Q.*, Prager, B.C. et al. CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity. Nat Commun 13, 1899 (2022).https://doi.org/10.1038/s41467-022-29469-0. (*Co-first author)
2021
Qiao Lu*, Jia Liu*, Shuai Zhao*, Maria Florencia Gomez Castro, Maudry Laurent-Rolle, Jianbo Dong, Xiaojuan Ran, Payal Damani-Yokota, Hongzhen Tang, Triantafyllia Karakousi, Juhee Son, Maria E. Kaczmarek, Ze Zhang, Stephen T. Yeung, Broc T. McCune, Rita E. Chen, Fei Tang, Xianwen Ren, Xufeng Chen, Jack C.C. Hsu, Marianna Teplova, Betty Huang, Haijing Deng, Zhilin Long, Tenny Mudianto, Shumin Jin, Peng Lin, Jasper Du, Ruochen Zang, Tina Tianjiao Su, Alberto Herrera, Ming Zhou, Renhong Yan, Jia Cui, James Zhu, Qiang Zhou, Tao Wang, Jianzhu Ma, Sergei B. Koralov, Zemin Zhang, Iannis Aifantis, Leopoldo N. Segal, Michael S. Diamond, Kamal M. Khanna, Kenneth A. Stapleford, Peter Cresswell, Yue Liu, Siyuan Ding#, Qi Xie#, Jun Wang#, SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2, Immunity,Volume 54, June 2021, Pages 1304-1319.e9, https://doi.org/10.1016/j.immuni.2021.05.006. (*Co-first author,#Co-corresponding author)
Wang D, Prager BC, Gimple RC, Aguilar B, Alizadeh D, Tang H, Lv D, Starr R, Brito A, Wu Q, Kim LJY, Qiu Z, Lin P, Lorenzini MH, Badie B, Forman SJ, Xie Q#, Brown CE#, Rich JN#. CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies. Cancer Discov. 2021 May;11(5):1192-1211. https://doi.org/10.1158/2159-8290.CD-20-1243. (#Co-corresponding author)
Zhen Xia, Min Tang, Jiayan Ma, Hongyan Zhang, Ryan C Gimple, Briana C Prager, Hongzhen Tang, Chongran Sun, Fuyi Liu, Peng Lin, Yutang Mei, Ruoxin Du, Jeremy N Rich, Qi Xie, Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase, Nucleic Acids Research, Volume 49, Issue 13, 21 July 2021, Pages 7361–7374, https://doi.org/10.1093/nar/gkab517.
2020
Tang, M.*, Xie, Q*#., Gimple, R.C. et al. Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. Cell Res 30, 833–853 (2020). https://doi.org/10.1038/s41422-020-0338-1 (*Co-first author,#Co-corresponding author)
2019
Gimple RC, Kidwell RL, Kim LJY, Sun T, Gromovsky AD, Wu Q, Wolf M, Lv D, Bhargava S, Jiang L, Prager BC, Wang X, Ye Q, Zhu Z, Zhang G, Dong Z, Zhao L, Lee D, Bi J, Sloan AE, Mischel PS, Brown JM, Cang H, Huan T, Mack SC, Xie Q#, Rich JN#. Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling. Cancer Discov. 2019 Sep;9(9):1248-1267. https://doi.org/10.1158/2159-8290.CD-19-0061. (#Co-corresponding author)
Prager BC*, Xie Q*, Bao S, Rich JN. Cancer Stem Cells: The Architects of the Tumor Ecosystem. Cell Stem Cell. 2019 Jan 3;24(1):41-53. https://doi.org/10.1016/j.stem.2018.12.009 (*Co-first author)
Before 2018
Xie Q*, Wu TP*, Gimple RC*, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, Dowiak AV, Lin K, Zeng C, Sui Y, Kim LJY, Miller TE, Jiang L, Lee CH, Huang Z, Fang X, Zhai K, Mack SC, Sander M, Bao S, Kerstetter-Fogle AE, Sloan AE, Xiao AZ, Rich JN. N6-methyladenine DNA Modification in Glioblastoma. Cell. 2018 Nov 15;175(5):1228-1243.e20. https://doi.org/10.1016/j.cell.2018.10.006. (*Co-first author)
Miller, T.E., Liau, B.B., Wallace, L.C., Morton, A.R., Xie, Q., Dixit, D., Factor, D.C., Kim, L.J.Y., Morrow, J.J., Wu, Q., et al. (2017). Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Nature 547:355-359. https://doi.org/10.1038/nature23000
Xie Q, Wu Q, Kim L, Miller TE, Liau BB, Mack SC, Yang K, Factor DC, Fang X, Huang Z, Zhou W, Alazem K, Wang X, Bernstein BE, Bao S, Rich JN. RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. J Clin Invest. 2016 Jul 1;126(7):2757-72. https://doi.org/10.1172/JCI86114
Xie, Q., Wu, Q., Horbinski, C.M., Flavahan, W.A., Yang, K., Zhou, W., Dombrowski, S.M., Huang, Z., Fang, X., Shi, Y., et al. (2015). Mitochondrial control by DRP1 in brain tumor initiating cells. Nature neuroscience 18:501-5. https://doi.org/10.1038/nn.3960
Xie, Q., Flavahan W.A., Bao S., Rich J. (2014) The Tailless Root of Glioma: Cancer Stem Cells. Cell Stem Cell 15(2):114-6 https://doi.org/10.1016/j.stem.2014.07.004