Cancer stem cell is a sub-population of cancer cells defined by sustained self-renewal, persistent proliferation, and tumor initiation capacity. Cancer stem cells play an essential role in tumor metastasis, recurrence, angiogenesis, chemotherapy and radiotherapy resistance, and immune evasion. Therefore, therapeutic strategies targeting cancer stem cells will bring new hope to the treatment of cancer.
Dr. Qi Xie’s research focuses on the epigenetic, transcriptional, post-translational, and metabolic regulation of cancer stem cells and their crosstalk with tumor microenvironment. He has published more than 20 papers including first author papers published in the top Journals such as Cell, Cancer Discovery, Immunity, Nature Neuroscience, Cell Research and Journal of Clinical Investigation. He has also been invited to write review and preview articles in Cell Stem Cell. He is currently a member of the American Cancer Society (AACR Member, since 2016), and is an independent reviewer for several journals including Clinical Cancer Research, Neuro-Oncology, and Cancer Letter.
We are particularly interested in the following directions:
1. Epigenetic and metabolic regulation of cancer stem cells
2. Crosstalk between tumor stem cells and tumor microenvironment
3. Improvement of tumor immunotherapy (CAR-T, CAR-NK, etc.)